PT  - JOURNAL ARTICLE
AU  - Vilor-Tejedor, Natalia
AU  - Evans, Tavia E.
AU  - Adams, Hieab H.
AU  - González-de-Echávarri, José María
AU  - Molinuevo, José Luis
AU  - Guigo, Roderic
AU  - Gispert, Juan Domingo
AU  - Operto, Grégory
TI  - Genetic Influences on Hippocampal Subfields
AID  - 10.1212/NXG.0000000000000591
DP  - 2021 Jun 01
TA  - Neurology Genetics
PG  - e591
VI  - 7
IP  - 3
4099  - http://ng.neurology.org/content/7/3/e591.short
4100  - http://ng.neurology.org/content/7/3/e591.full
SO  - Neurol Genet2021 Jun 01; 7
AB  - There is clear evidence that hippocampal subfield volumes have partly distinct genetic determinants associated with specific biological processes. The identification of genetic correlates of hippocampal subfield volumes may help to elucidate the mechanisms of neurologic diseases, as well as aging and neurodegenerative processes. However, despite the emerging interest in this area of research, the current knowledge of the genetic architecture of hippocampal subfields has not yet been consolidated. We aimed to provide a review of the current evidence from genetic studies of hippocampal subfields, highlighting current priorities and upcoming challenges. The limited number of studies investigating the influential genetic effects on hippocampal subfields, a lack of replicated results and longitudinal designs, and modest sample sizes combined with insufficient standardization of protocols are identified as the most pressing challenges in this emerging area of research.AD=Alzheimer disease; ASHS=automatic segmentation of hippocampal subfields; CA=cornu ammonis; DG=dentate gyrus; GWAS=genome-wide association study; MAGeT=Multiple Automatically-GEnerated Templates; MDD=major depressive disorder; SNP=single nucleotide polymorphism; SRLM=subiculum and stratum radiatum/stratum lacunosum/stratum moleculare