RT Journal Article
SR Electronic
T1 Genetic risk scores and hallucinations in patients with Parkinson disease
JF Neurology Genetics
JO Neurol Genet
FD Lippincott Williams & Wilkins
SP e492
DO 10.1212/NXG.0000000000000492
VO 6
IS 5
A1 Cynthia D.J. Kusters
A1 Kimberly C. Paul
A1 Aline Duarte Folle
A1 Adrienne M. Keener
A1 Jeff M. Bronstein
A1 Valerija Dobricic
A1 Ole-Bjørn Tysnes
A1 Lars Bertram
A1 Guido Alves
A1 Janet S. Sinsheimer
A1 Christina M. Lill
A1 Jodi Maple-Grødem
A1 Beate R. Ritz
YR 2020
UL http://ng.neurology.org/content/6/5/e492.abstract
AB Objective We examine the hypothesized overlap of genetic architecture for Alzheimer disease (AD), schizophrenia (SZ), and Parkinson disease (PD) through the use of polygenic risk scores (PRSs) with the occurrence of hallucinations in PD.Methods We used 2 population-based studies (ParkWest, Norway, and Parkinson's Environment and Gene, USA) providing us with 399 patients with PD with European ancestry and a PD diagnosis after age 55 years to assess the associations between 4 PRSs and hallucinations after 5 years of mean disease duration. Based on the existing genome-wide association study of other large consortia, 4 PRSs were created: one each using AD, SZ, and PD cohorts and another PRS for height, which served as a negative control.Results A higher prevalence of hallucinations was observed with each SD increase of the AD-PRS (odds ratio [OR]: 1.37, 95% confidence interval [CI]: 1.03–1.83). This effect was mainly driven by APOE (OR: 1.92, 95% CI: 1.14–3.22). In addition, a suggestive decrease and increase, respectively, in hallucination prevalence were observed with the SZ-PRS and the PD-PRS (OR: 0.77, 95% CI: 0.59–1.01; and OR: 1.29, 95% CI: 0.95–1.76, respectively). No association was observed with the height PRS.Conclusions These results suggest that mechanisms for hallucinations in PD may in part be driven by the same genetic architecture that leads to cognitive decline in AD, especially by APOE.AD=Alzheimer disease; aOR=adjusted odds ratio; CI=confidence interval; GWAS=genome-wide association study; MDS-UPDRS=Movement Disorder Society–Unified Parkinson Disease Rating Scale; MMSE=Mini-Mental State Examination; PD=Parkinson disease; PEG=Parkinson's Environment and Gene; PK=ParkWest; PRS=polygenic risk score; SZ=schizophrenia