Article Figures & Data
Figures
- Figure 1 GAA1 Length Is Predictive of Blood Frataxin Level and Age of Onset Only in Sub-cohorts of Patients With Less Than 700 GAA Triplets
Linear regression analysis comparing GAA1 length with blood frataxin level (A) and age of onset (AoO) (B) in the entire cohort (All samples) and for subgroups stratified by GAA1 length. Correlation coefficient (R2) values are plotted for each subgroup. Black data points represent results for patients with less than or equal to the GAA1 cutoffs listed on the X-axis (e.g., less than or equal to 200 triplets, 300 triplets). Red data points represent results for patients with greater than the GAA1 cutoffs listed on the X-axis (e.g., greater than 200 triplets, 300 triplets). Filled data points indicate p < 0.01; open data points indicate n.s. Linear regression plots comparing GAA1 length with blood frataxin level (C) and AoO (D) for the entire cohort stratified by GAA1 less than or equal to 700 triplets (gray circles, black fit line) or more than 700 triplets (white circles, red fit line).
- Figure 2 Predictions of Neurological Dysfunction by Disease Duration Are Better in the Sub-cohort of Patients With >700 GAA Triplets Compared to the Entire Cohort
- Figure 3 Prevalence of Cardiomyopathy and Scoliosis Increases in Patient Cohorts as GAA1 Length Increases Until It Plateaus at 700 GAA Triplets
Prevalence of cardiomyopathy (A), scoliosis (B), and diabetes (C) for the entire cohort (n = all) and for sub-cohorts stratified by GAA1 length.
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