Article Figures & Data
Figures
- Figure 1 Regional Brain Volume Trajectories in the TRACK-HD Cohort
Regional brain volume trajectories in the TRACK-HD cohort. (A-J) Individual regional volume trajectories, with PreHD individuals in solid orange lines, HD individuals in dashed red lines, GPPM average fit as a solid black line, and GPPM uncertainty as shaded red lines. (K) All regional volume trajectories overlaid. Standardized volumes (y-axis) are shown, and the time-scale (x-axis) is centered such that t = 0 when the fitted trajectory (black line) is equal to the mean value of the HD group. Uncertainty in the fit is shown as light shading about the mean and was estimated using 200 samples from the posterior. GPPM = Gaussian Process Progression Model; HD = manifest Huntington disease; PreHD = pre-manifest Huntington disease.
- Figure 2 Time and Magnitude of Regional Brain Volume Trajectories in the TRACK-HD Cohort
Time and magnitude of regional brain volume trajectories in the TRACK-HD cohort. (A) Predicted maximum change times for ten regional volumes from genotype-positive trajectories in TRACK-HD. Box-plots represent the mean, upper and lower bounds from 1,000 samples from the posterior. Extreme values are represented as black circles, while the green bars indicate the medians. (B) Average magnitude of change of each volume.
- Figure 3 Selected Regional Brain Volume Trajectories by CAG Repeat Count in the TRACK-HD Cohort
Selected regional brain volume trajectories inferred by GPPM from gene-positive (PreHD and HD) individuals from the TRACK-HD cohort, grouped by CAG repeat count. Standardized volumes (y-axis) are shown, and the time-scale (x-axis) is centered such that t = 0 when the fitted trajectory is equal to the mean value of the HD group. Uncertainty in the fit is shown as light shading about the mean and was estimated using 200 samples from the posterior. CAG = cytosine-adenine-guanine; GPPM = Gaussian Process Progression Model; HD = manifest Huntington disease; PreHD = pre-manifest Huntington disease.
- Figure 4 Group-Level Staging Density in the TRACK-HD and PREDICT-HD Cohorts
(A) TRACK-HD and (B) PREDICT-HD. Distributions were fit using a nonparametric density function (KDE: kernel density estimate). HD = manifest Huntington disease; PreHD = pre-manifest Huntington disease.
- Figure 5 Predicted Time to Onset in the PREDICT-HD Cohort
(A) Difference (residual) between actual and predicted time to onset for GPPM and SM, for PreHD individuals from PREDICT-HD. Boxplots show the median, first and third quartiles, and outliers. (B) Predicted and true time to onset for each model. Fits are from fixed effect linear models, with shaded bands corresponding to 95% confidence intervals. GPPM = Gaussian Process Progression Model; SM = survival model.
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