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Figures
- Figure Scheme of the Structural and Functional Relationships of APP
Asterisks indicate pathogenic APP mutations that have been identified in familial AD, which cluster near the α-secretase, β-secretase (BACE1), and γ-secretase cleavage sites. AD = Alzheimer disease; APP = amyloid precursor protein; BACE1 = β-site APP cleaving enzyme-1.
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