Genetic risk scores and hallucinations in patients with Parkinson disease
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Article Information
- Received April 6, 2020
- Accepted in final form May 26, 2020
- First Published July 20, 2020.
Author Disclosures
- Cynthia D.J. Kusters, MD, PhD,
- Kimberly C. Paul, MPH, PhD,
- Aline Duarte Folle, MS,
- Adrienne M. Keener, MD,
- Jeff M. Bronstein, MD, PhD,
- Valerija Dobricic, PhD,
- Ole-Bjørn Tysnes, MD,
- Lars Bertram, MD, PhD,
- Guido Alves, MD, PhD,
- Janet S. Sinsheimer, PhD,
- Christina M. Lill, MD, MSc,
- Jodi Maple-Grødem, PhD and
- Beate R. Ritz, MD, PhD
- Cynthia D.J. Kusters, MD, PhD,
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(1) NIH, T32HG002536, trainee for the Training Grant in Genomic Analysis and Interpretation, 2016-2018(2) NIH, F32AG063442, postdoctoral fellow, 2019-2020
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(1) Burrough Wellcome Fund Fellowship
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- Kimberly C. Paul, MPH, PhD,
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(1) NIEHS, R01-ES010544, Post Doc Employee, 2016 (2) NIEHS, F32-ES028087, PI, 2017-2019
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- Aline Duarte Folle, MS,
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- Adrienne M. Keener, MD,
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American Parkinson Disease Association Pilot Project (December 1, 2016 - August 30, 2017)
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- Jeff M. Bronstein, MD, PhD,
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Neurology International, Associate editor, 2011-present
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Clinical trials with US WorldMeds, LLC, Global Kinetics, and Wilson's Therapeutics.
1) NIEHS, 2R01-ES010544, Co-I, 02/01/11-01/31/15 2) NIEHS, PI, 5R21ES16446-2, 3/6/09-2/28/11 3) NINDS, Co, 5P50NS038367-07, 5/1/06-4/30/12 4) NIEHS, Project PI, 1P01ES016732-08/10/2008-6/2013 5) Veterans Administration Healthcare System Center, PI, no number, 5/2001-ongoing
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Levine Foundation
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- Valerija Dobricic, PhD,
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- Ole-Bjørn Tysnes, MD,
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Given lectures for several pharmaceutical companies
Acta Neurologica Scandinavica. More than 10 years
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- Lars Bertram, MD, PhD,
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Neurogenetics, Associate Editor, since 2007 European Journal of Clinical Investigation, Associate Editor, since 2009 International Journal of Molecular Epidemiology and Genetics, Associate Editor, since 2010 International Journal of Alzheimer's Disease, Guest editor, 2010-2011 Human Mutation, Communicating Editor, since 2012
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- Guido Alves, MD, PhD,
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(1) Abbvie, speaker honoraria
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(1) Norwegian Research Council, grant# 287842, Principal investigator, 2019-2022
(1) University of Stavanger
(1) Norwegian Parkinson Research Foundation (2) Reberg's Legacy
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- Janet S. Sinsheimer, PhD,
data safety monitoring board non-profit: The Lundquist Institute, Harbor-UCLA Medical Center IRB Study 20399-01 IND 104,354 An Extension Study of Intrathecal Enzyme Replacement for Cognitive Decline in Mucopolysaccharidosis I Agnes Chen, MD Principal Investigator
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Wellcome Genome Campus Advanced Courses Funding for air travel and honoraria of ∼$1500 US
Annals of Applied Statistics Associate Editor 2011 to Current
1. Method to estimate age of individual based on epigenetic markers in biological sample E. Vilain, S. Bocklandt, S. Horvath, J. Sinsheimer US Patent App. 14/119,145 Statistical approach to methylation data analysi 2. Genetic variants associate with human-directed hyper-social behavior in domestic dogs B. vonHoldt, M. Udell, J. Sinsheimer US Patent 17-3362-1 (in process) Genotyping of a specific region of dog genome
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Ongoing Research NIH/NIMH R21 MH115825 (PI: A. Levine) 9/1/18-6/20/20 Project Title: Bardoxolone: A Novel Treatment for HIV-Associated Neurocognitive Disorders Role: Co-Investigator The major goal of this project is to further characterize the safety and efficacy of Bardoxolone for treating and/or preventing HAND. No Relationship to the current study NIH/NHGRI U01 HG007703 (PIs: S. Nelson, C. Palmer, J. Martinez) 7/01/14 Â 6/30/22 Project Title: UCLA Site for the investigation of undiagnosed disorders Role: Co-Investigator The Major Goals of this Project are: To understand how genomic data can contribute to diagnosis of rare/undiscovered disease. No Relationship to the current study NIH/NHGRI HG009120 (PI: B. Pasaniuc) 3/01/17-2/28/22 Project Title: Integrative Approaches for mapping the Genetic Risk of Complex Traits Role: Co-Investigator The goal of this project is to develop new statistical approaches using summary statistics from genomic studies to map genes for complex traits. No Relationship to the current study Recently Completed NIH/NHLBI HL095056 (PI: P. Pajukanta) 3/01/17-2/28/19 Project Title: Genomics of Dyslipemia in Mexicans Role: Co-Investigator The major goal of this project is to understand the genetic and epigenetic determinants of dyslipidemia in Mexicans, whose susceptibility is significantly higher than other ethnic groups in the US. No Relationship to the current study NIH/NHLBI P01 HL028481 (PI: A. J. Lusis) 7/1/15Â 6/30/19 Project Title: Molecular Genetic Approaches in Atherosclerosis Research Role: Co-Investigator (Statistical Core) The Major Goals of this Project are: To determine the genes involved in common atherosclerotic diseases. No Relationship to the current study NIH/NIGMS R01 GM053275Â (PI: K. Lange) 4/1/16 Â 3/31/20 Project Title: Statistical Methods for Gene Mapping Role: Co-Investigator The major goal of this project is to address some of the computational issues arising in human gene mapping. No Relationship to the current study NIH/NIEHS ES023451 (PI: B. Ritz) 5/01/15-4/30/20 Project Title: Environment and Cognitive Decline in Older Hispanics Role: Co-Investigator The major goal of the proposed research is to investigate whether long-term exposure to air pollution and pesticides, contribute to cognitive decline and dementia in elderly Mexican Americans. No Relationship to the current study
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- Christina M. Lill, MD, MSc,
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Gene, Frontiers Neurol
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(1) intramural funding of the University of Lübeck
(1) German Research Foundation (DFG; LI 2654/2-1) (2) Possehl Foundation (3) Renate Maaà Foundation (4) Michael J Fox Foundation
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- Jodi Maple-Grødem, PhD and
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(1) The Norwegian Parkinson's Association(2) The National Association for Public Health (#14846)
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- Beate R. Ritz, MD, PhD
Scientific Advisory Board Member for the State of California Air Toxics Board
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Consultant for a study conducted at the University of Southern California with funding from the Komen Foundation
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NIEHS R21ES022391 PI 2012-15 NIEHS R21ES022734 Co-I 07/01/13 - 06/30/15 NIEHS R21ES022389 Co-I 01/01/14 - 12/31/15 NIEHS R21ES019986 PI 2012- 2015 NIEHS R01ES010544 PI 2011-2016 NIEHS R03ES021643 Co-I 04/01/12-03/31/15 NCI R21CA175959 Co-I 04/01/14-03/31/16 NIA R01AG042511 Co-I 2013-16 NIEHS R21ES024356 PI 2014-2016 NIEHS R21ES024006 (mPI)2015-17 NIEHS R21ES25573 (PI: Ritz) 2015-17 NIEHS R21ES030175 (PI: Ritz) 2019-2020 NNH12ZDA006O-EVI3 (PI: Ritz) NASA 2016-2025 Cal Air Resources Board CARB (Co-I) 2019-2021 NIA 1U01AG060908 Co-I 2018-23 DoD (Co-I) 2019-21
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Foundation for Psychocultural research (TheFPR.org) funds students and postdocs at UCLA APDA grant for the UCLA center for excellency in PD research MJFox Foundation
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expert testimony, acted as a witness or consultant for plaintiffs in legal suits for pesticide exposure and cancer and pesticide exposure and Parkinson's disease
- From the Department of Epidemiology (C.D.J.K., K.C.P., A.D.F., B.R.R.), UCLA Fielding School of Public Health, Los Angeles, CA, USA; Department of Human Genetics (C.D.J.K., J.S.S.), David Geffen School of Medicine, Los Angeles, CA; Department of Neurology (A.M.K., J.M.B., B.R.R.), David Geffen School of Medicine, Los Angeles, CA; Parkinson's Disease Research (A.M.K.), Education, and Clinical Center, Greater Los Angeles Veterans Affairs Medical Center, Los Angeles, CA; Brain Research Institute (J.M.B.), University of California, Los Angeles, CA; Lübeck Interdisciplinary Platform for Genome Analytics (V.D., L.B.), Institutes of Neurogenetics & Cardiogenetics, University of Lübeck, Lübeck, Germany; Department of Neurology (O.-B.T.), Haukeland University Hospital, Bergen, Norway and University of Bergen, Bergen, Norway; Department of Clinical Medicine (O.-B.T.), University of Bergen, Bergen, Norway; Department of Psychology (L.B.), Centre for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo, Norway; The Norwegian Center for Movement Disorders (G.A., J.M.-G.), Stavanger University Hospital, Stavanger, Norway; Department of Neurology (G.A.), Stavanger University Hospital, Stavanger, Norway; Department of Chemistry (G.A., J.M.-G.), Bioscience and Environmental Engineering, University of Stavanger, Stavanger, Norway; Department of Biostatistics (J.S.S.), UCLA Fielding School of Public Health, Los Angeles, CA; Department of Computational Medicine (J.S.S.), David Geffen School of Medicine, Los Angeles, CA; Section for Translational Surgical Oncology and Biobanking (C.M.L.), Department of Surgery, University of Lübeck and University Medical Center Schleswig-Holstein, Campus Lübeck, Lübeck; Ageing Epidemiology Research Unit (C.M.L.), School of Public Health, Imperial College, London, United Kingdom; and Department of Environmental Health (B.R.R.), UCLA Fielding School of Public Health, Los Angeles, CA.
- Correspondence
Dr. Kusters ckusters{at}ucla.edu
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