Share

December 2019; 5 (6) ArticleOpen Access

Migraine polygenic risk score associates with efficacy of migraine-specific drugs

Lisette J.A. Kogelman, Ann-Louise Esserlind, Anne Francke Christensen, Swapnil Awasthi, Stephan Ripke, Andres Ingason, Olafur B. Davidsson, Christian Erikstrup, Henrik Hjalgrim, Henrik Ullum, Jes Olesen, Thomas Folkmann Hansen, DBDS Genomic Consortium, The International Headache Genetics Consortium
First published October 24, 2019, DOI: https://doi.org/10.1212/NXG.0000000000000364
Full PDF
Citation
Permissions

Make Comment

See Comments

Downloads
1281

Share

Article Figures & Data

Figures

  • Figure 1
    Figure 1 Association of the polygenic risk score with acute treatment response

    ORs and the 95% CI are shown on the left-hand side, and the corresponding forest plot is shown on the right-hand side. An OR below 1 represents a lower response rate to the drug. An OR above 1 represents a higher response rate to the drug. Migraine-specific acute treatment includes both triptan and ergotamine, as both are acting on the same 5-HT1B/D receptors. Migraine nonspecific treatment is represented by the weak analgesics. CI = confidence interval; OR = odds ratio.

  • Figure 2
    Figure 2 Associations of the polygenic risk score with prophylactic treatment response

    ORs and the 95% CI are shown on the left-hand side, and the corresponding forest plot is shown on the right-hand side. An OR below 1 represents a lower response rate to the drug. An OR above 1 represents a higher response rate to the drug. Acute treatment includes both triptan and ergotamine, as both are acting on the same 5-HT1B/D receptors. Prophylactic treatment response includes all questioned treatments summed up (positive response to any prophylactic drug vs response to none). ACE = angiotensin-converting enzyme; CI = confidence interval; OR = odds ratio.

  • Figure 3
    Figure 3 Replication of the association of the polygenic risk score (PRS) with acute treatment response

    Odds ratio by PRS within each 20 percentiles for n = 5,616 triptan users in the Danish Blood Donor Study replication cohort.

Letters: Rapid online correspondence

No comments have been published for this article.
Comment

REQUIREMENTS

You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.

Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.

If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.

Submission specifications:

  • Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
  • Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
  • Submit only on articles published within 6 months of issue date.
  • Do not be redundant. Read any comments already posted on the article prior to submission.
  • Submitted comments are subject to editing and editor review prior to posting.

More guidelines and information on Disputes & Debates

Compose Comment

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
NOTE: The first author must also be the corresponding author of the comment.
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. [email protected]
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Publishing Agreement
NOTE: All authors, besides the first/corresponding author, must complete a separate Publishing Agreement Form and provide via email to the editorial office before comments can be posted.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

You May Also be Interested in

Back to top
Advertisement

Related Articles

Alert Me

Recommended articles