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August 2019; 5 (4) ArticleOpen Access

Systematic review and meta-analysis of cardiac involvement in mitochondrial myopathy

Asfia Quadir, Carly Sabine Pontifex, Helen Lee Robertson, Christopher Labos, View ORCID ProfileGerald Pfeffer
First published June 12, 2019, DOI: https://doi.org/10.1212/NXG.0000000000000339
Asfia Quadir
From the Hotchkiss Brain Institute (A.Q., C.S.P., G.P.), University of Calgary; Health Sciences Library (H.L.R.), University of Calgary, Alberta; Queen Elizabeth Health Complex (C.L.), Montreal, Quebec; and Department of Clinical Neurosciences (G.P.), Cumming School of Medicine, University of Calgary, Alberta, Canada.
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Carly Sabine Pontifex
From the Hotchkiss Brain Institute (A.Q., C.S.P., G.P.), University of Calgary; Health Sciences Library (H.L.R.), University of Calgary, Alberta; Queen Elizabeth Health Complex (C.L.), Montreal, Quebec; and Department of Clinical Neurosciences (G.P.), Cumming School of Medicine, University of Calgary, Alberta, Canada.
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Helen Lee Robertson
From the Hotchkiss Brain Institute (A.Q., C.S.P., G.P.), University of Calgary; Health Sciences Library (H.L.R.), University of Calgary, Alberta; Queen Elizabeth Health Complex (C.L.), Montreal, Quebec; and Department of Clinical Neurosciences (G.P.), Cumming School of Medicine, University of Calgary, Alberta, Canada.
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Christopher Labos
From the Hotchkiss Brain Institute (A.Q., C.S.P., G.P.), University of Calgary; Health Sciences Library (H.L.R.), University of Calgary, Alberta; Queen Elizabeth Health Complex (C.L.), Montreal, Quebec; and Department of Clinical Neurosciences (G.P.), Cumming School of Medicine, University of Calgary, Alberta, Canada.
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Gerald Pfeffer
From the Hotchkiss Brain Institute (A.Q., C.S.P., G.P.), University of Calgary; Health Sciences Library (H.L.R.), University of Calgary, Alberta; Queen Elizabeth Health Complex (C.L.), Montreal, Quebec; and Department of Clinical Neurosciences (G.P.), Cumming School of Medicine, University of Calgary, Alberta, Canada.
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  • ORCID record for Gerald Pfeffer
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Citation
Systematic review and meta-analysis of cardiac involvement in mitochondrial myopathy
Asfia Quadir, Carly Sabine Pontifex, Helen Lee Robertson, Christopher Labos, Gerald Pfeffer
Neurol Genet Aug 2019, 5 (4) e339; DOI: 10.1212/NXG.0000000000000339

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    Figure 1 PRISMA flowchart

    PRISMA = Preferred Reporting Items for Systematic Reviews and Meta-Analyses.

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    Figure 2 Prevalence of ECG abnormalities with ES (95% CI) in adult participants

    Note that patients are reported according to genetic defect (upper portion of the figure) and according to their clinical syndrome (lower portion of figure), and some patients may be duplicated if both a genetic defect and clinical syndrome was provided. This equally applies to figures 3–5. ES = effect size; mtDNA = mitochondrial DNA.

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    Figure 3 Prevalence of ECG abnormalities with ES (95% CI) in pediatric participants

    ES = effect size.

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    Figure 4 Prevalence of echocardiography abnormalities with ES (95% CI) in adult participants

    ES = effect size; mtDNA = mitochondrial DNA.

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    Figure 5 Prevalence of echocardiography abnormalities with ES (95% CI) in pediatric participants

    ES = effect size.

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  • Reader response: Systematic review and meta-analysis of cardiac involvement in mitochondrial myopathy
    • Josef Finsterer, Neurologist, KAR
    Submitted August 21, 2019
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