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- Figure 1 Genetic correlation between atrial fibrillation (AF) in the AF Genetics (AFGen) Consortium meta-analysis and AF and ischemic stroke subtypes analyzed in SiGN
Pearson r correlation between SNP z-scores in the AFGen GWAS of AF and in GWAS of selected traits performed in the SiGN data. (A) GWAS of AF in AFGen and in SiGN correlate with increasing strength as SNP z-scores in AFGen increase. Correlation with educational attainment (performed separately, shown here as a null comparator) remains approximately zero across all z-score thresholds. (B) SNP effects in AFGen also correlate strongly with cardioembolic stroke in SiGN, but not with the other primary stroke subtypes. (C) Undetermined subtypes of stroke also show modest correlation with the genetic architecture of AF in AFGen. Panels (D–F) show genome-wide z-score distributions underlying correlations. Shading of the hexagons indicates the density of the data at that point, where darker shading indicates a higher density of SNPs. GWAS = genome-wide association studies.
- Figure 2 Association of atrial fibrillation (AF) polygenic risk score in ischemic stroke subtypes
We constructed an independent polygenic risk score (PRS) from AF-associated SNPs identified in the AFGen GWAS and tested associations between this PRS and ischemic stroke subtypes using (A) all available referents (N = 28,026) and (B) referents without AF (N = 3,861). The PRS strongly associated with cardioembolic stroke in both sets of samples. In the AF-free set of controls (panel B), we observed association of the PRS (p < 5 × 10−3, after adjusting for 5 subtypes and 2 sets of referents; indicated by the dashed dark blue line) with incomplete/unclassified stroke as well. GWAS = genome-wide association studies; PRS = polygenic risk score.
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