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December 2017; 3 (6) ArticleOpen Access

NaV channel variants in patients with painful and nonpainful peripheral neuropathy

Samir Wadhawan, Saumya Pant, Ryan Golhar, Stefan Kirov, John Thompson, Leslie Jacobsen, Irfan Qureshi, Senda Ajroud-Driss, Roy Freeman, David M. Simpson, A. Gordon Smith, Ahmet Hoke, Linda J. Bristow; On behalf of the Foundation for Peripheral Neuropathy and the Peripheral Neuropathy Research Registry (PNRR) Consortium
First published December 15, 2017, DOI: https://doi.org/10.1212/NXG.0000000000000207
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Article Information

vol. 3 no. 6 e207
DOI: 
https://doi.org/10.1212/NXG.0000000000000207
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Online ISSN: 
2376-7839
History: 
  • Received July 25, 2017
  • Accepted in final form October 2, 2017
  • First Published December 15, 2017.
Copyright & Usage: 
Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

Author Disclosures

    1. Samir Wadhawan, PhD,
    2. Saumya Pant, PhD,
    3. Ryan Golhar, PhD,
    4. Stefan Kirov, PhD,
    5. John Thompson, PhD,
    6. Leslie Jacobsen, MD,
    7. Irfan Qureshi, MD,
    8. Senda Ajroud-Driss, MD,
    9. Roy Freeman, MD,
    10. David M. Simpson, MD,
    11. A. Gordon Smith, MD, FAAN,
    12. Ahmet Hoke, PhD, MD and
    13. Linda J. Bristow, PhD On behalf of the Foundation for Peripheral Neuropathy and the Peripheral Neuropathy Research Registry (PNRR) Consortium
  1. Samir Wadhawan, PhD,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. 1) Bristol-Myers Squibb, Senior Research Investigator, 2yrs

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Saumya Pant, PhD,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. (1)Biocon Bristol-Myers Squibb R&D Centre, India, Associate Research Director, 2016-2017 (2)Bristol- Myers Squibb,Senior Research Investigator, 2014-2016.

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Employee of Bristol-Myers Squibb

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Ryan Golhar, PhD,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. Bristol-Myers Squibb Senior Research Investigator 3 yrs

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Stefan Kirov, PhD,
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. Bristol Myers Squibb, Principal Research Investigator, 10

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. John Thompson, PhD,
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. Bristol-Myers Squibb, Research Fellow, 3 years

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Bristol-Myers Squibb

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. Bristol-Myers Squibb, 3 years

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Leslie Jacobsen, MD,
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. I was a full time employee of Bristol-Myers Squibb during the time that this work was completed.

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. I was awarded BMS stock during the period that this work was completed

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Irfan Qureshi, MD,
    8. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. Employee of Bristol-Myers Squibb

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. Bristol-Myers Squibb

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  8. Senda Ajroud-Driss, MD,
    9. Scientific Advisory Boards:

    1. 1- MT Pharma 2- Alnylam

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. hereditary spastic paraplegia, up to date, last updated 7/17

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. MT Pharma

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Alnylam Viromed

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Foundation for peripheral neuropathy

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  9. Roy Freeman, MD,
    10. Scientific Advisory Boards:

    1. Abide, Acetylon, Astellas, Biogen, Daiichi-Sankyo, Dong, Grace, Grunental, Insys, Lundbeck, Nestle, Novartis, Pfizer, Vertex and Spinifex

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Autonomic Neuroscience - Basic and Clinical, Editor (2007-2016) Autonomic Neuroscience - Basic and Clinical, Editor-in-Chief (2016-) Clinical Autonomic Research, Editorial Board (1999-present) Clinical Journal of Pain, Assoc. Editor, 2009-2012 Clinical Journal of Pain, Editorial Board (2009-present)

    Patents:

    1. NONE

    Publishing Royalties:

    1. Royalties from UptoDate

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. (1) Impeto (2) Nestle (3) Pfizer

    Research Support, Government Entities:

    1. (1) NIH (NHBLI), R01HL111465-01A1, PI 08/27/13-06/30/17 (2) NIH (NINDS), U54 NS 065736, Co-PI, 09/30/15-06/30/2020

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Multiple system atrophy consortium

    Stock/Stock Options/Board of Directors Compensation:

    1. (1) Spinifex

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  10. David M. Simpson, MD,
    11. Scientific Advisory Boards:

    1. Scientific advisory board: Allergan,Merz,Ipsen DSMB: Axsome

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Speaker honoraria: Allergan, Merz, Ipsen

    Editorial Boards:

    1. AIDS Patient Care (2008-current)

    Patents:

    1. NONE

    Publishing Royalties:

    1. Neuropathic Pain: Mechanisms, Diagonosis and Management; Oxford; 2012

    Employment, Commercial Entity:

    1. Icahn School of Medicine at Mount Sinai

    Consultancies:

    1. Allergan, Merz, Ipsen

    Speakers' Bureaus:

    1. Allergan, Merz, Ipsen

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Allergan, Merz, Ipsen

    Research Support, Government Entities:

    1. NINDS: R01-NS328-05-co-inv; R24 MH59724-co-inv;R01-NS- 41198-co-inv; NIMH-00-AI-0005-co-PI

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Foundation for Peripheral Neuropathy

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. Proctor and Gamble: 2012-2017

  11. A. Gordon Smith, MD, FAAN,
    12. Scientific Advisory Boards:

    1. Celegene Data Monitoring Committee

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Editor for NeuroLearn

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. (1) Regenesis (2) Allergan (3) Viromed

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. (1) Impeto Medical SAS

    Research Support, Government Entities:

    1. (1) DK064814 PI 2004-2014 NIDDK (2) U10NS077305 PI 2011-2018 NINDS (3) U10NS086606 CoI 2013-2018 NINDS

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  12. Ahmet Hoke, PhD, MD and
    13. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Editor-in-Chief, Experimental Neurology Associate editor, Annals of Clinical Translational Neurology

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. Johns Hopkins University, Professor

    Consultancies:

    1. (1) Neurocrine Inc.

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIH R01 NS091260 (role: PI); MSCRF MSCRFI-0715 (role: PI); NSF DMR- 1410240 (role: co-investigator); DOD OR160032 (role: PI)

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Foundation for peripheral neuropathy The Dr. Miriam and Sheldon G. Adelson Medical Research Foundation

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. National Vaccine Injury Program: gave expert testimony on GBS Arnold & Porter Kaye Scholer LLP: gave expert testimony on peripheral neuropathy

  13. Linda J. Bristow, PhD On behalf of the Foundation for Peripheral Neuropathy and the Peripheral Neuropathy Research Registry (PNRR) Consortium
    14. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. (1) Bristol-Myers Squibb, Group Director, 9 years.

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. (1) Bristol-Myers Squibb

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. (1) stock in Bristol Myers Squibb, 2009-present

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

    1. From the Department of Translational Biomarkers and Computational Genomics (S.W., S.P., R.G., S.K., J.T.), Bristol-Myers Squibb, Hopewell Site, Pennington, NJ; Department of Genetically Defined Diseases Discovery Biology (L.J.B.), Bristol-Myers Squibb, Wallingford, CT; Department of Innovative Clinical Development (I.Q., L.J.), Bristol-Myers Squibb, Lawrenceville, Princeton, NJ; Department of Neurology (S.A.-D.), Northwestern Medical Faculty Foundation, Chicago, IL; Department of Neurology (R.F.), Beth Israel Medical Center, Harvard School of Medicine, Boston, MA; Department of Neurology (D.M.S.), Icahn School of Medicine at Mount Sinai Medical Center, New York, NY; Department of Neurology (A.G.S.), University of Utah School of Medicine, Salt Lake City, UT; Department of Neurology (A.H.), Johns Hopkins University, Baltimore, MD. S.P. is currently affiliated with Biocon Bristol-Myers Squibb Research Center, Bangalore, India.
    1. Correspondence to Dr. Bristow: Linda.Bristow{at}Sunovion.com
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