Design and rationale for examining neuroimaging genetics in ischemic stroke
The MRI-GENIE study
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Article Information
- Received March 9, 2017
- Accepted in final form June 30, 2017
- First Published August 24, 2017.
Author Disclosures
- Anne-Katrin Giese, MD,
- Markus D. Schirmer, PhD,
- Kathleen L. Donahue, BS,
- Lisa Cloonan, BA,
- Robert Irie, PhD,
- Stefan Winzeck, MS,
- Mark J.R.J. Bouts, PhD,
- Elissa C. McIntosh, MA,
- Steven J. Mocking, MSc,
- Adrian V. Dalca, PhD,
- Ramesh Sridharan, PhD,
- Huichun Xu, MD, PhD,
- Petrea Frid, MD,
- Eva Giralt-Steinhauer, MD, PhD,
- Lukas Holmegaard, MD,
- Jaume Roquer, MD, PhD,
- Johan Wasselius, MD, PhD,
- John W. Cole, MD,
- Patrick F. McArdle, PhD,
- Joseph P. Broderick, MD,
- Jordi Jimenez-Conde, MD, PhD,
- Christina Jern, MD, PhD,
- Brett M. Kissela, MD, MS,
- Dawn O. Kleindorfer, MD,
- Robin Lemmens, MD, PhD,
- Arne Lindgren, MD, PhD,
- James F. Meschia, MD,
- Tatjana Rundek, MD, PhD,
- Ralph L. Sacco, MD, MS,
- Reinhold Schmidt, MD,
- Pankaj Sharma, MD, PhD,
- Agnieszka Slowik, MD, PhD,
- Vincent Thijs, MD, PhD,
- Daniel Woo, MD, MS,
- Bradford B. Worrall, MD, MSc,
- Steven J. Kittner, MD, MPH,
- Braxton D. Mitchell, PhD, MPH,
- Jonathan Rosand, MD, MSc,
- Polina Golland, PhD,
- Ona Wu, PhD* and
- Natalia S. Rost, MD, MPH* On behalf of MRI-GENIE
- Anne-Katrin Giese, MD,
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NIH-NINDS R01NS086905, Research Fellow (Rost ? PI)
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- Markus D. Schirmer, PhD,
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- Kathleen L. Donahue, BS,
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NIH-NINDS R01NS086905, Research Coordinator (Rost ? PI)
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- Lisa Cloonan, BA,
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(1) Decision Resources Group, Business Insights Analyst, 2015-Present
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- Robert Irie, PhD,
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(1) Department of Defense (DoD), travel (TDY) for official duties as civilian employee of DoD, unrelated to study.
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- Stefan Winzeck, MS,
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- Mark J.R.J. Bouts, PhD,
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Leiden University, Leiden The Netherlands
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- Elissa C. McIntosh, MA,
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- Steven J. Mocking, MSc,
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Google, Software Engineer, 3 years (my involvement with the study precedes this employment)
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- Adrian V. Dalca, PhD,
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(1) Imaging Genetics, Editor, 2017
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(1) Imaging Genetics, Elsevier, 2017
(1) Massachusetts Institute of Technology, Research Assistant, 2009-2017
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(1) I am employed by Massachusetts General Hospital, which is a part of Partners Healthcare, a non-profit. I am a Postdoctoral Fellow (2) Wife is also employed by Partners Healthcare
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(1) MIT
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- Ramesh Sridharan, PhD,
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- Huichun Xu, MD, PhD,
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US Priority No. and Date: US20070915366P, May 01, 2007; International Application No. and Filing Date: PCT/US2008/062064, on April 30, 2008, publication date 13.11.2008; publication number WO 2008/137465 (A1). Methods for diagnosing etiologies of ischemic stroke by detecting expression levels of genes
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NIH, R01NS086905, co-PI, 7/1/2015-4/30/2020 NIH, R01 HL136574, co_PI, 4/1/2017-3/31/2021
(1) University of Maryland Claude D. Pepper Older Americans Independence Center (UM-OAIC)
(1).AHA
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- Petrea Frid, MD,
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- Eva Giralt-Steinhauer, MD, PhD,
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- Lukas Holmegaard, MD,
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- Jaume Roquer, MD, PhD,
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This study was supported in part by Spain?s Ministry of Health (Ministerio de Sanidad y Consumo, Instituto de Salud Carlos III FEDER, RD16/0019/0002. INVICTUS-PLUS).
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- Johan Wasselius, MD, PhD,
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- John W. Cole, MD,
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Book entitled: Stroke Essentials for Primary Care, Alway, David; Cole, John Walden (Eds., 2009, Springer, ISBN: 978-1-934115-01-5
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- Patrick F. McArdle, PhD,
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09/23/05-06/30/15 NIH U01HL105198 Pharmacogenomics of Anti-platlet Intervention-2 (PAPI-2) Study Role: Investigator
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- Joseph P. Broderick, MD,
Astra Zeneca for Socrates study. Monies go to Department
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Travel expenses reimbursed by Universities as part as invited Visiting Professor over past 2 years - approximately 4-5 times per year. Honoraria for speaking placed in faculty academic fund within department.
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Method for Controlling the Lysis of Coagulated Blood with Apolipoprotein e4 Phenotype. US Patent 7, 135, 305, issued November 15, 2006. Also, a closely related patent in 2007.
Elsevier as co-editor of Book
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Pfizer 2014-2015 for work on new potential treatment for ICH. All monies paid to Department for educational/research fund.
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Monies paid to Department of Neurology by Genentech for role on PRISMS Trial steering committee
NINDS-funded CLEARER and STOP-IT Clinical Trials) P50 NS44283, 2002 to 2016, PI for NIH funded National Coordinating Center for NIH StrokeNet 2013 to present. Co-investigator (Previous PI) of NINDS-funded Genetic and Environmental Risk Factors for Hemorrhagic Stroke NIH-NINDS R01 NS36695 1998-present, Co- investigator (Previous PI) NINDS-funded ?Comparison of Hemorrhagic and Ischemic Strokes Among Blacks and Whites
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- Jordi Jimenez-Conde, MD, PhD,
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IMIM-Hospital del Mar, Adjunct Neurologist
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(1) NINDS/NI, U01NS069208, Center PI,2011-14, (2) ISCIII/Spanish Government Grants, PI10/02064, PI, 2011-13,(3)ISCIII/Spanish Government Grants, PI15/00451, PI, 2015-18,
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La Marat? TV3,76/C/2011, PI, 2012-15 Recercaixa 2013, JJ086116, PI, 2014-2016
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- Christina Jern, MD, PhD,
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(1) The Sahlgrenska Academy and the Sahlgrenska University, ALFGBG-148861, PI, 2011-2014 (2) The Swedish Medical Research Council, K2014-64X-14605-12- 5, PI, 2014-2018
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(1) The Swedish Heart Lung Foundation (2) The Swedish Stroke Foundation
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- Brett M. Kissela, MD, MS,
Ipsen Pharmaceuticals
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I have received compensation to perform event adjudication for clinical trials sponsored by Janssen and AbbVie.
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NIH funding for multiple grants
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- Dawn O. Kleindorfer, MD,
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1) Genentech, speaker's bureau travel, 2008-present
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Genentech, modest level
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R01 NS30678 Kissela and Kleindorfer (PI) 4/1/2015 ? 3/30/2020 3.60 cal mos NIH $7,578,621 Hemorrhagic and Ischemic Stroke Among Blacks and Whites (EPI) Role: Co-PI U01 NS041588 Howard (PI) ? Kissela (Site PI) 09/24/2011 ? 11/30/2017 3.00 cal mos Subaward w/Univ of Alabama Birmingham $116,286 ?Etiology of Geographic and Racial Differences in Stroke (REGARDS)? U01NS086872 (Broderick) 09/30/2013 ? 07/31/2018 2.40 cal mos NIH/NINDS $1,623,735 ?NSTN National Clinical Coordinating Center? U10 NS086512 (Khatri/Kleindorfer) 09/30/2013 ? 07/31/2018 1.80 cal mos NIH/NINDS $250,000 ?Cincinnati Regional Coordinating Stroke Center (Cincinnati RCC)?
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- Robin Lemmens, MD, PhD,
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FWO Flanders: Senior Clinical Investigator, 2012-2017, 1841913N FWO Flanders: Research Grant 2015-2019: basic science grant G070015N HORIZON 2020: PROOF 2017-2019 no role in this study
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- Arne Lindgren, MD, PhD,
(1)Astra Zeneca (2)Bristol-Myers Squibb (3)Boehringer Ingelheim (4)Sanofi (5)Pfizer (6)Bayer (7)Reneuron
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(1)Astra Zeneca (2)Bristol-Myers Squibb (3)Boehringer Ingelheim (4)Sanofi (5)Pfizer (6)Bayer
(1) Neurologi i Sverige. Editorial advisory board member.
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- James F. Meschia, MD,
I Chair the data safety monitoring board for the NINDS NeuroNEXT clinical trail network.
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On the editorial boards of Mayo Clinic Proceedings and the European Journal of Neurology.
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Dr. Meschia receives support from the NINDS for efforts devoted to the MRI-GENIE study.
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- Tatjana Rundek, MD, PhD,
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1. Stroke, assistant editor, 2013- 2. Neurology, editorial board member, 2010- 3. Cerebrovascular Disease, editorial board member, 2010- 4. Journal of Ultrasound in Medicine, editorial board member, 2010-
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NINDS R37 NS 029993-11 (Co-Investigator), 2000- NINDS K24 NS 062737 (Principal Investigator), 2009-2016 NINDS R01 NS 065114 (Principal Investigator), 1010-2017
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- Ralph L. Sacco, MD, MS,
DSMB for SOCRATES Trial through UCSF(indirect sponsor Astra Zeneca) and EUCLID trial through Duke Clinical Research Institute (indirect sponsor Astra Zeneca).
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Ed Boards: Stroke, Neuroepidemiology
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Prior consultant for Boehringer Ingelheim
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Boehringer Ingelheim - Past Consultant and current institutional research support from Boehringer Ingelheim for Steering Committee of Secondary Stroke Prevention Trial with Dabigatran (RESPECT ESUS Trial)
(1) NINDS, Northern Manhattan Study, PI, 1993-present R01 NS29993 (2) NINDS, Family Study, PI, 2004-present R01 NS040807 (3) NINDS Stroke Prevention Interveniton Research Program, PI, 2013-present
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Evelyn McKnight Brain Institute; American Heart Association Bugher Foundation
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- Reinhold Schmidt, MD,
Rivastigmin Patch, 2010, Novartis JSW Life Sciences 2010, Advisory Board for Dementia Trial Axon Neuroscience 2013 2014, 2015-2017
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Received travel expenses and/or honoraria for lectures from Pfizer (2004-2010), Novartis (2003-2010), Merz Austria (2005-2010) and Lundbeck (2004-2009) and for educational activity from Takeda 2010, Axon Neuroscience 2015
Editoral board member of Clinical Neurology and Neurosurgery 2004-currently
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Pfizer 2004-2010,lectures Novartis 2003-2010,2014 lectures Merz Austria 2005-2010, lectures Lundbeck 2004-2009, lectures Takeda, 2010, teaching course Merz Austria 2009-3017
QPS, Austria Axon Neuroscience
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Austrian Science Fund projects P20103 and I904
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- Pankaj Sharma, MD, PhD,
Bohringer 2009 & 2013 advisory board member 2013-14 Bayer advisory board member
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J Royal Soc Medicine Cardiovascular Disease Editor in Chief
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- Agnieszka Slowik, MD, PhD,
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- Vincent Thijs, MD, PhD,
(1) Bayer (2) Boehringer Ingelheim (3) Amgen (4) Pfizer/BMS (5) Daiichi Sankyo
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(1) Bayer (2) Boehringer Ingelheim (3) Amgen (4) Pfizer/BMS (5) Daiichi Sankyo (6) Medtronic
Acta Neurologica Belgica, Associate Editor 2012-Ongoing Stroke, Editorial Board, 2012-Ongoing International Journal of Stroke, Editorial Board, 2016-Ongoing European Stroke Journal, Editorial Board, 2015-Ongoing European Journal of Emergency Medicine, 2009-Ongoing
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(1) Bayer (2) Boehringer Ingelheim (3) Amgen (4) Pfizer/BMS (5) Daiichi Sankyo (6) Medtronic
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NIH, NINDS, SIGN grant
VIB Flanders
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- Daniel Woo, MD, MS,
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(1) Stroke Research and Treatment, Associate Editor, 2010-2014.
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NIH Funding: NS36695 (PI: 1998-Current); NS30678 (CoI: 1998-Current). NS69763 (PI: 2010-Current).
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- Bradford B. Worrall, MD, MSc,
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Neurology: Associate Editor 1 July 2009 - September 2015; Deputy Editor October 2015 - present Seminars in Neurology Editorial Board 2006-2014
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Chapter Author for Merritt's Neurology editions 10, 11, and 12.
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NINDS/NIH - R01 NS 069763 (co-investigator) 2010-2016 NINDS/NIH ? U-01 NS069208 (co-Prinicpal Investigator) 2010-2015 NHGRI/NIH ? U-01 HG005160 (co-Principal Investigator) 2009-2014
University of Virginia - CENETERS OF EXCELLENCE CLINICAL RESEARCH GRANT SUPPORT - The UVA BRAIN AND AORTIC ANEURYSM SCREENING (BAAS) study - Principal Investigator 10/13-4/17
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- Steven J. Kittner, MD, MPH,
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Editorial Board, Neuroepidemiology, 2000- present
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NINDS: 1U01NS069208, Co-PI, 2010-2016 NINDS: R01NS069763-01, Site PI
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Atlantic States Insurance, Review of Medical Case, 2013
- Braxton D. Mitchell, PhD, MPH,
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Diabetes, Associate Editor, 2009 - 2016
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1. NIH P30DK072488,Co-Director, 2011 - 2019 2. NIH U01NS069208, Co-Investigator, 2010 - 2015 3. NIH R01NS073346, Co-Investigator, 2011 ? 2015 4. NIH R01NS086905, Co-Investigator, 2016 ? 2020
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- Jonathan Rosand, MD, MSc,
Pfizer, DSMB
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Lancet Neurology, editorial board member Stroke, editorial board member
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NIH/NINDS
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- Polina Golland, PhD,
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University of Utah School of Computing Vising Committee
Editorial Board of Journal of Medical Image Analysis, 2008- present
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Wistron Corporation, research grant
NIH
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- Ona Wu, PhD* and
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(1) RSNA, reimbursement for travel to Annual QIBA Meeting (2) NIH, reimbursement for travel for serving on study section review panels
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(1) Delay-compensated calculation of tissue blood flow (2) Method for evaluating novel, stroke treatments using a tissue risk map
(1) Nobel Prize Internet Archive, 2013
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(1) Penumbra, Inc.
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(1) Genentech
(1) NIH/NINDS, P50NS051343, Principal Investigator, 2011-2016 (2) MGH Executive Committee on Research, N/A, Principal Investigator, 2015-2017 (3) NIH/NINDS, R01NS082285, Investigator, 2014-2017 (4) NIH/NINDS, U01NS086625, Investigator, 2014-2017 (5) NIH/NINDS, R01NS086905, Investigator, 2016-2017 (6) NIH/NINDS, R01NS083654, Investigator, 2016-2017 (7) NIBIB,HHSN268201500021C (H-1), Principal Investigator, 2015-2017 (8) Football Players Health Study at Harvard University, N/A, Pricipal Investigator, 2016 (9) NIH/NINDS, R01NS063925, Principal Investigator, 2009-2012 (10) NIH/NINDS, U01NS069208, Investigator, 2010-2014
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(1) US Patent 7,512,435. 2009 Mar 31; Royalty Distribution from General Electric, Olea Medical, Imaging Biometrics, 2010-2017
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- Natalia S. Rost, MD, MPH* On behalf of MRI-GENIE
(1) Genzyme Co., (2) Merck, (3) Boston Biomedical Associates, (4) Omniox, (5) BioTelemetry
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(1) Stroke, Assistant Editor, 2010 - current; (2) Current Treatment Options in Cardiovascular Medicine, Section Editor, 2014 - current.
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UpToDate (
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(1) Genzyme Co., (2) Merck, (3) Boston Biomedical Associates, (5) Omniox
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NIH/NINDS R01NS082285 (PI), 2013 -current NIH/NINDS R01NS086905 (PI), 2015 - current
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- Correspondence to Dr. Rost: nrost{at}partners.org
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