Clinical and genetic study of hereditary spastic paraplegia in Canada
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Article Information
- Received June 30, 2016
- Accepted in final form October 20, 2016
- First Published December 5, 2016.
Author Disclosures
- Nicolas Chrestian, MD,
- Nicolas Dupré, MD,
- Ziv Gan-Or, MD, PhD,
- Anna Szuto, MSc,
- Shiyi Chen, MSc,
- Anil Venkitachalam, MD,
- Jean-Denis Brisson, MD,
- Jodi Warman-Chardon, MD,
- Sohnee Ahmed, MSc,
- Setareh Ashtiani, MSc,
- Heather MacDonald, MSc,
- Noreen Mohsin, BSc,
- Karim Mourabit-Amari, MD,
- Pierre Provencher, MSc,
- Kym M. Boycott, MD, PhD,
- Dimitri J. Stavropoulos, PhD,
- Patrick A. Dion, PhD,
- Peter N. Ray, PhD,
- Oksana Suchowersky, MD,
- Guy A. Rouleau, MD, PhD and
- Grace Yoon, MD
- Nicolas Chrestian, MD,
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- Nicolas Dupré, MD,
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Actelion Pharmaceuticals
Cerebellum & Ataxia
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- Ziv Gan-Or, MD, PhD,
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Sanofy/genzyme, travel fees and speaker honoraria
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(1) Canadian Institute of Health Research, Post-doctoral fellowship, post-doctoral fellow, 2014-2016
(1) McGill University
(1) Michael J. Fox Foundation
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- Anna Szuto, MSc,
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- Shiyi Chen, MSc,
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- Anil Venkitachalam, MD,
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- Jean-Denis Brisson, MD,
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- Jodi Warman-Chardon, MD,
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- Sohnee Ahmed, MSc,
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I am currently employed by GeneDx from January 2016 as a laboratory genetic counselor. This commercial entity is not related to this manuscript at all, as I did not join this company until well after the data and manuscript were compiled/written.
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- Setareh Ashtiani, MSc,
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- Heather MacDonald, MSc,
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CIHR Emerging Team Grant, in collaboration with the Canadian Organization for Rare Disorders (CORD), grant number RN127580-260005, research genetic counselor, 1 year
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- Noreen Mohsin, BSc,
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- Karim Mourabit-Amari, MD,
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- Pierre Provencher, MSc,
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- Kym M. Boycott, MD, PhD,
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(1)Human Molecular Genetics, Editorial Advisory Board Member, 2015-present. (2) Genetics, Editorial Advisory Board Member, 2015- present. (3) Molecular Genetics and Genomic Medicine; Editorial Advisory Board Member, 2014-present.
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- Dimitri J. Stavropoulos, PhD,
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- Patrick A. Dion, PhD,
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- Peter N. Ray, PhD,
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- Oksana Suchowersky, MD,
Abbvie,
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American Academy of Neurology - speaker and course director, annual meetings, 2015, 2016
Editorial Board - Canadian Journal of Neurological Sciences 2005-2016, Nature Reviews Neurology 2010-ongoing
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UpToDate - chapters on Diagnosis of Huntington Disease, Treatment of Huntington Disease, and Diagnosis of Chorea, yearly ongoing updates on these 3 chapters
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Advisory Boards for Abbott(Abbvie), and Ipsen
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Abbvie - CADENCE and OBSERVE studies 2015-2016 Biotie - TOZ-Cl05 2016-ongoing
Steady -PD , NIH funded (multi-center)Local PI, 2014- ongoing Dystonia Coalition, NIH funded (multicenter), Local PI, 2013-2016 Hereditary Spastic Paraplegia, CIHR funded (multicenter), Co-investigator of clinical arm, 2012-ongoing
Funded Chair, Toupin Foundation, University of Alberta
Enroll-HD, funded by CHDI, Local PI, 2010-ongoing
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- Guy A. Rouleau, MD, PhD and
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(1) CIHR Foundation Scheme (FDN-143260); 07/2015 to 06/2022; 708,381$/year. Genetic & Biological Studies of Brain Disorders. Role: Principal Applicant (2) ALS Society of Canada, 09/2013 to 08/2015. Assessment of somatic mutations and repeat instability in known ALS genes. Role: Principal Applicant. (3) ALS Association (OJ3X54), 08/2012 to 07/2015. Characterization of C9ORF72 expansion stability in ALS/FTD patients. Role: Principal Applicant.
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- Grace Yoon, MD
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This study was funded by CIHR Emerging Team Grant, in collaboration with the Canadian Organization for Rare Disorders (CORD), grant number RN127580 ? 260005, 2012-2017. The funding organization had no role in design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript.
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- From the Division of Neurology (N.C., G.Y.), Division of Clinical and Metabolic Genetics (S. Ahmed, H.M., G.Y.), Department of Paediatrics, University of Toronto, The Hospital for Sick Children; Faculty of Medicine (N.C., N.D., J.-D.B., K.M.-A.), Laval University, Quebec City; Department of Neurological Sciences (N.D., P.P.), CHU de Québec; Department of Neurology and Neurosurgery (Z.G.-O., N.M., P.A.D., G.A.R.), McGill University, Montreal Neurological Institute, Quebec; Department of Medical Genetics (A.S.), University of Montreal, CHUM, Quebec; The Hospital for Sick Children Research Institute (S.C.), Child Health Evaluative Sciences/Biostatistics Design & Analysis Unit, Toronto, Ontario; Department of Medicine (A.V., O.S.), Division of Neurology, Department of Medical Genetics (S. Ashtiani, O.S.), University of Alberta, Edmonton; Department of Genetics (J.W.-C., K.M.B.), Children's Hospital of Eastern Ontario, Ottawa; CHU de Québec (K.M.-A.), Hôpital Enfant-Jésus, Quebec City; Department of Paediatric Laboratory Medicine (D.J.S., P.N.R.), The Hospital for Sick Children, Toronto, Ontario; and Department of Molecular Genetics (P.N.R.), The University of Toronto, Canada.
- Correspondence to Dr. Yoon: grace.yoon{at}utoronto.ca
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