TREM2 p.R47H substitution is not associated with dementia with Lewy bodies
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Article Information
- Received February 18, 2016
- Accepted in final form June 15, 2016
- First Published July 14, 2016.
Author Disclosures
- Ronald L. Walton, BSc*,
- Alexandra I. Soto-Ortolaza, BSc*,
- Melissa E. Murray, PhD,
- Oswaldo Lorenzo-Betancor, MD, PhD,
- Kotaro Ogaki, MD, PhD,
- Michael G. Heckman, MS,
- Sruti Rayaprolu, BSc,
- Rosa Rademakers, PhD,
- Nilüfer Ertekin-Taner, MD, PhD,
- Ryan J. Uitti, MD,
- Jay A. van Gerpen, MD,
- Zbigniew K. Wszolek, MD,
- Glenn E. Smith, MD,
- Kejal Kantarci, MD,
- Val J. Lowe, MD,
- Joseph E. Parisi, MD,
- David T. Jones, MD,
- Rodolfo Savica, MD, PhD,
- Jonathan Graff-Radford, MD,
- David S. Knopman, MD,
- Ronald C. Petersen, MD, PhD,
- Neill R. Graff-Radford, MD,
- Tanis J. Ferman, PhD,
- Dennis W. Dickson, MD,
- Bradley F. Boeve, MD,
- Owen A. Ross, PhD and
- Catherine Labbé, PhD
- Ronald L. Walton, BSc*,
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- Alexandra I. Soto-Ortolaza, BSc*,
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- Melissa E. Murray, PhD,
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BMC Neurology, Associate Editor
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- Oswaldo Lorenzo-Betancor, MD, PhD,
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- Kotaro Ogaki, MD, PhD,
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- Michael G. Heckman, MS,
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- Sruti Rayaprolu, BSc,
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- Rosa Rademakers, PhD,
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Patents held: 'Detecting and Treating Dementia, 12/302,691 (2008) and 'Methods and Materials for Detecting and Treating Dementia' 12/413,869 (2009)
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National Institutes of Health: (1) Mayo Clinic Udall Center of Excellence: P50NS072187 (2) R01 NS080882 (3) P01 NS084974 (4) R01 NS076471
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(1) ALS Therapy Alliance; (2) Consortium for Frontotemporal Dementia; (3) Florida State Alzheimers Disease Research grant
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- Nilüfer Ertekin-Taner, MD, PhD,
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Editorial Board Member for American Journal of Neurodegenerative Disease.
Human Monoclonal Antibodies Against Amyloid Beta Protein, and Their Use as Therapeutic Agents Application (pending).
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1) National Institutes of Health [R01 AG032990], PI, 2009-2012 2) National Institutes of Health [P50 AG016574], Project PI, 2009-2014 (PI: Ronald Petersen) 3) National Institutes of Health [R01 NS080820], PI, 2013-2018. 4) National Institutes of Health [U01AG046139], MPI, 2013-2018 5) National Institutes of Health [RF1AG051504], MPI, 2015-2020.6) National Institutes of Health [R21AG048101], MPI, 2015-2017
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1) CurePSP, PI, 2012-2014 2) Bright Focus, PI, 2013-2016 3) Florida Health Ed and Ethel Moore Alzheimer?s Disease Research Program Grant, PI, 2015
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- Ryan J. Uitti, MD,
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Associate Editor - NEUROLOGY
LRRK2 - Mayo Clinic
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ANS/St. Jude Medical - 2005-present research study
NINDS - Udall Center 2004-present
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PARFF - 2008-2009
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- Jay A. van Gerpen, MD,
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I receive research funding from the NIH based on my participation on the UDALL center grant given to the Mayo Clinic.
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- Zbigniew K. Wszolek, MD,
Mayo Clinic and Mayo Foundation salery
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Parkinsonism and Related Disorders, Co-Editor-in-Chief, since 2008; European Journal of Neurology, Associate Editor, since 2007; Neurologia i Neurochirurgia Polska, Editorial Board Member, since 2004; Medical Jornal of the Rzeszow University and the National Medicines Institute, Warsaw, Editorial Board Member, since 2011; Clinical and Experimental Medical Letters, Editorial Board Member, since 2006; Translational Neuroscience, Editorial Board Member, 2009-2015; Medycyna Praktyczna - Neurologia, Editorial Board Member, since 2010
Mayo file # 2004-185: Identification of mutations in PARK8, a locus for familial Parkinson?s disease, Disclosure date: 07/28/2004; Mayo file # 2004-291: Identification of a novel LRRK2 mutation, 6055G>A (G2019S), linked to autosomal dominant parkinsonism in families from several European populations, Disclosure date: 12/10/2004.
Parkinsonism and Related Disorders, Elsevier, 2015, 2016; European Journal of Neurology, Wiley-Blackwell, 2015, 2016
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NIH/NINDS P50 NS072187; NIH/NIA (primary) and NIH/NINDS (secondary) 1U01AG045390-01A1
Mayo Clinic Center for Regenerative Medicine, Mayo Clinic Center for Individualized Medicine, Mayo Clinic Florida Neuroscience Focused Research Team grants
The gift from Carl Edward Bolch, Jr., and Susan Bass Bolch and The Sol Goldman Charitable Trust
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- Glenn E. Smith, MD,
1) University of Wisconsin Alzheimer's Disease Center External Advisory Board (non-profit) 2009-present. Honoraria
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International Congress on Alzheimer Disease (Alzheimer's Assn/Non-profit, travel funds only 2010 and 2011). American Academy of Clinical Neuropsychology, 2013 and 2016 (Non-profit), American Board of Professional Psychology, 2015, (non-profit), National Academy of Neuropsychology, 2015 (non-profit).
1) Then Clinical Neuropsychologist (2008-2012) 2) Journal of International Neuropsychological Society (2008-2010)
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Mild Cognitive Impairment and Dementia; Definitions, Diagnosis and Treatment, Oxford University Press, 2013 Handbook of Dementia, American Psychological Association (forthcoming)
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1) Homeinstead Senior Living Inc (commercial) Consulted on their staff dementia training program. 2011
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National Center for Research Resources Rizza (PI) U54 RR 24150 Mayo Clinic Center for Clinical and Translational Research Co-investigator, Chair, Post- doctoral programs, Leader of Behavioral Sciences core National Institute on Aging (Co-PI) 5/04 ? 4/14 AG16574 Information Transfer Core, Mayo Clinic Alzheimer?s Disease Research Center.Principal Investigator National Institute on Aging Ferman TA (PI) 10/1/05- 9/30/10AG15866 Neuropsychology of Dementia with Lewy Bodies Role: Co-investigator National Institute on Neurological Disease & Stroke Kramer P(PI) Subcontract of NS6-2366-02 Tasks of Executive Function.Role: Site PI
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Patient Centered Outcomes Research Institute; CER-1306-01897 (PI) PPRN-1501-26817 (CoPI)
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- Kejal Kantarci, MD,
Data safety monitoring board member for Takeda Global Research & Development Center, Inc., Pfizer Inc. and Janssen Alzheimer Immunotherapy
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R01 AG040042 (PI); 2011-2016, P50AG044170/P2(PI); 2012- 2017;
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Minnesota Partnership for Biotechnology and Medical Genomics; 2013-2015
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- Val J. Lowe, MD,
(1) Piramal Imaging
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(1) GE Health Care (2) AVID Radiopharmaceuticals
(1) NIA R01 DC010367-01, CoI, 12/01/09-11/30/14 (2) NIA P50 AG016574-12, Co-PI Project #1, 05/01/09- 04/30/14 (3) NIA R01 AG011378-16, CoI, 06/01/08-05/31/13 (4) NCI R01 R01CA 200551-1 , CoI, 02/01/16-11/30/19 (6) P50 CA102701-07, CoI, 09/01/08-08/31/13 (7) R01 CA125614-04 , CoI,09/26/06-07/31/11 (8) R21 CA123909-02, CoI, 07/01/07-08/01/12 (9) U01AG 06786-30, CoI, 07/01/07-06/30/19 (10) UM1CA 186686-2,CoI, 04/17/14-02/28/19 (11) R01 AG41851-4, CoI, 04/01/12-03/28/17 (12)P50 AG44170-4, CoI, 09/01/12-05/31/17 (13)R01 DC012519-1, CoI, 07/01/13-06/30/18 (14)R01CA 154348-4, CoI, 07/18/14-12/31/16 (15)R21AG 47984-1, PI, 09/01/15-05/31/17 (16)R01NS 89757-1, CoI, 09/15/15-08/31/20
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(1) MN Partnership for Biotechnology and Medical Genomics (2) Elsie and Marvin Dekelboum Family Foundation (3) Leukemia & Lymphoma Society (4) Liston Family Foundation
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- Joseph E. Parisi, MD,
06/2011 - Present; Defense Health Board Healthcare Delivery Subcommittee, Member
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Oxford, Principles & Practice of Neuropathology, 2nd ed, 2003
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NIH NS32352-13
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- David T. Jones, MD,
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- Rodolfo Savica, MD, PhD,
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- Jonathan Graff-Radford, MD,
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- David S. Knopman, MD,
Consultant Bluefield project (frontotemporal demantia); Lundbeck Pharmaceuticals (Sept 2013 ongoing); DIAN study DSMB (Sept 2013 ongoing).
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(1) Lectures, Alzheimer Conference, Seoul Korea, December 2014 (2) Lectures, Behavioral Neurology Conference, Hyderabad, India
Associate Editor Neurology, ended October 2015
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(1) Tau Rx clinical trial funded by TAURX (site PI) (2) A4 clinical trial partially funded by Lilly (site PI) (3) Biogen Alzheimer Study (site PI)
NIH: R01-AG11378 ongoing, P50-AG 16574 (Mayo Alzheimer?s Disease Research Center) ongoing, U01 AG 06786 (Mayo Alzheimer Disease Patient Registry) ongoing. 1U01HL096917-01 ARIC Dementia Study. AG 037551 Chronic Kidney Disease and Cognitive functioning.
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- Ronald C. Petersen, MD, PhD,
(1) Pfizer, Inc., Chair, Data Monitoring Committee; (2) Janssen Alzheimer Immunotherapy, Chair, Data Monitoring Committee
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Mild Cognitive Impairment,Oxford University Press, 2003
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(1) Roche Incorporated, (2) Merck, (3) Genentech, (4) Biogen, (5) Eli Lilly
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National Institute on Aging: U01-AG006786 (PI) (1986-present) P50-AG016574 (PI) (1990-present) R01-AG011378 (Co-I) U01-AG024904 (Co-I)
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- Neill R. Graff-Radford, MD,
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(1) Alzheimer Disease and Therapy, Editorial Board
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I received royalties for an article in UpToDate
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(1) TauRx FTD multicenter study (2) Lilly multicenter study (3) Biogen multicenter study
(1) NIA P50AG16574 coinvestigator ADRC; (2) NIA U24AG26395 Site PI LOAD study; (3) NIA U01AG24904 Site PI ADNI; (4) NIA R01AG06656 Coinvestigator
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- Tanis J. Ferman, PhD,
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NIH/NIA R01 AG15866, Principal Investigator 2005-2010 NIH/NIA P50AG16574, Co-investigator 2005-present NINDS P50NS072187, Co-investigator 2010-present Mangurian Foundation for Lewy body dementia research, Co- Investigator 2010-present
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- Dennis W. Dickson, MD,
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Editorial board member: Acta Neuropathologica, Brain, Brain Pathology, Neurobiology of Aging, Annals of Neurology, Neuropathology; Editor: International Journal of Clinical and Experimental Pathology, American Journal of Neurodegenerative Disease.
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P50AG016574 (Core Leader); P50NS072187 (Center Director); P01NS084974 (Project Leader); P01AG003949 (Core Leader)
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Society for PSP: Foundation for PSP|CBD and Related Disorders Mangurian Foundation
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- Bradley F. Boeve, MD,
Tau Consortium
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Ionis Pharmaceuticals, 2015
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Grant support as an investigator in clinical trials funded by GE Healthcare, 2012-present; FORUM Pharmaceuticals, 2015-present; C2N Diagnostics, 2016- present.
NIH: P50 AG016574 (2009-present), U01 AG006786 (2009- present), RO1 AG032306 (2010-present), RO1 AG041797 (2012- present), UO1 AG045390 (2014-present), and U54 NS092089 (2014-present)
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Mangurian Foundation, 2011-present Little Family Foundation, 2015-present
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- Owen A. Ross, PhD and
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Editorial advisory board member: Parkinsonism and Related Disorders Molecular Neurodegeneration American Journal of Neurodegenerative Disease PLoS ONE
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(1) NINDS Udall Parkinson's Disease Research Center of Excellence P50 #NS072187; 2012-1017. (2)NINDS R01 NS078086; 2012-2017.
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Michael J. Fox Foundation
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- Catherine Labbé, PhD
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- From the Department of Neuroscience (R.L.W., A.I.S.-O., M.E.M., O.L.-B., K.O., S.R., R.R., N.E.-T., D.W.D., O.A.R., C.L.), Division of Biomedical Statistics and Informatics (M.G.H.), Department of Neurology (N.E.-T., R.J.U., J.A.v.G., Z.K.W., N.R.G.-R.), Department of Psychiatry and Psychology (T.J.F., O.A.R.), Mayo Clinic, Jacksonville, FL; Department of Biology (A.I.S.-O., O.A.R.), University of North Florida, Jacksonville; Department of Psychiatry and Psychology (G.E.S.), Department of Radiology (K.K., V.J.L., D.T.J.), Department of Laboratory Medicine and Pathology (J.E.P., B.F.B.), Department of Neurology (J.E.P., D.T.J., R.S., J.G.-R., D.S.K., R.C.P.), Mayo Clinic, Rochester, MN; Department of Clinical and Health Psychology (G.E.S.), University of Florida, Gainesville; and Mayo Graduate School (T.J.F., O.A.R.), Neurobiology of Disease, Jacksonville, FL.
- Correspondence to Dr. Labbé: labbe.catherine{at}mayo.edu
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